Cd161 and clec2d affinity
WebNov 4, 2011 · These findings correlate with the low affinity interaction between CD161 and LLT1, which shows a K D ∼48 μ m . Also, CD161-mediated inhibition in NK cells has been linked to the presence in the intracytoplasmic domain of CD161, of a sequence homologous to immunoreceptor tyrosine-based inhibitory motifs but displaying an alanine at position ... WebFeb 15, 2024 · We have previously identified 2B4 (SLAMF4), CS1 (SLAMF7) and LLT1 (CLEC2D) that can activate or inhibit NK cells upon the interaction with their ligands. ... (CD161), leading to the inhibition of NK-cell-mediated ... CS1 is a homophilic receptor that is self-activating, while 2B4 has a high affinity to CD48 as its ligand. CS1 and LLT1 were ...
Cd161 and clec2d affinity
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WebThe lone human NKR-P1A receptor (KLRB1/CD161/CLEC5B) possesses inhibitory function upon binding to the closest Clr-related ligand, LLT1 (CLEC2D/OCIL/CLAX) (47, 48). This interaction is functionally similar to the rodent NKR-P1B:Clr-b interaction; however, the receptor and ligand also share strong similarity with another rodent (putative ... WebJul 29, 2015 · CD161, or KLRB1, is a C-type lectin-like receptor expressed by the majority of natural killer (NK) cells 5 and in a subset of T cells, 6 and is particularly enriched in populations found in the...
WebNov 7, 2024 · Background The CLEC2D/CD161 axis is a novel ligand-receptor pathway for immunotherapeutic intervention. IMT-009 is a monoclonal, aglycosylated human IgG1 … WebThe invention relates generally to anti-CD161 antibodies, pharmaceutical compositions comprising such antibodies, and methods of using such antibodies for treating disorders associated with or mediated by CD161, for example, certain cancers. In addition, the invention also relates to expression vectors and host cells for making these antibodies.
WebWhile the biological function of CD161 is not clear, it has been suggested to serve either as a stimulatory receptor or to inhibit NK cell-mediated cytotoxicity and cytokine production. … WebMar 31, 2016 · View Full Report Card. Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn …
WebFeb 17, 2024 · Additionally, CLEC2D, the ligand for CD161, is a surface molecule expressed by myeloid cells and malignant cells, suggesting a ligand-receptor pathway for immunotherapy. Accordingly, functional experiments where KLRB1 was inactivated in primary human T cells using CRISPR/Cas9 showed that CD161 inhibits the anti-tumor …
WebOct 18, 2016 · Overexpression of LLT1 (OCIL, CLEC2D) on prostate cancer cells inhibits NK cell-mediated killing through LLT1-NKRP1A (CD161) interaction Prostate cancer is the most common type of cancer diagnosed and the second leading cause of cancer-related death in American men. st louis county mn hibbing mn court calendarWebDec 22, 2024 · One study described that CD161 binds LLT1 with entropically and enthalpically driven thermodynamics, fast kinetics, low affinity, and small heat capacity; there are typical cell-cell … st louis county mn jail commissaryWebMar 2, 2024 · As glioma cells have been reported to express the CD161 ligand CLEC2D, the authors hypothesized that the CD161 receptor could inhibit activation of T cell … st louis county mn ordinance 60WebFeb 15, 2024 · Gliomas include glioblastoma, the most aggressive and incurable type of brain tumor. The CD161 receptor is activated by a molecule called CLEC2D on tumor cells and immune-suppressing cells in the brain, according to the researchers. Activation of CD161 weakens the T cell response against tumor cells. st louis county mn privyWebMay 1, 2024 · Major Finding: In glioma, tumor-infiltrating cytotoxic T cells expressed the inhibitory NK-cell receptor CD161. Concept: Blocking the inhibitory CD161–CLEC2D pathway activated T cell–mediated killing of glioma cells. Impact: This work identifies the CD161 receptor as a novel immunotherapy target in glioma and other cancers. st louis county mn land parcel mapWebFeb 10, 2024 · Background The CLEC2D/CD161 axis is a novel ligand-receptor pathway for immunotherapeutic intervention. ... Results IMT-009 binds CD161 with high affinity and selectivity, blocking its interaction ... st louis county mn phhsst louis county mn property gis