Chondrocyte subtype
WebFeb 21, 2024 · Chondrocytes, which make up the majority of the cells in all samples, are further split into three empirically defined populations: cartilage progenitor cells (CPCs), fibrochondrocyte progenitors (FCPs), and homeostatic chondrocytes (HomCs), as well as four new populations known as C1–4 ( Figures 1D,F ). WebJun 21, 2024 · Lawrence Livermore National Laboratory (LLNL) scientists have profiled articular cartilage from healthy and injured mouse knee joints at a single-cell resolution and identified nine chondrocyte subtypes …
Chondrocyte subtype
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WebAs expected, all chondrocyte subtypes showed significant enrichment for the ontology terms 'cartilage development' and 'ECM organization' ( Figure 4 A). However, many of the cartilage ECM genes ... The number of chondrocyte cells created and their maturation process can be influenced by multiple different genes and proteins. Two proteins, bone morphogenetic protein 4(BMP-4) and fibroblast growth factor 2(FGF2) have been seen to influence the amount of differentiation into chondrocytes. Both proteins are known to play a role in embryonic stem cell differentiation into mesodermal cells, through signaling with BMP-4 and as FGF2 acting as a stimulator. From the …
WebMar 9, 2024 · Chondrocyte inflammation and pyroptosis have been shown to play important roles in osteoarthritis (OA). In this study, we investigated the effects of exercise-induced irisin during different intensities of treadmill exercise in a rat OA model and the anti-inflammatory and antipyroptosis mechanism of irisin in OA chondrocytes. WebNov 15, 2024 · Chondrocyte is the only cell type present in mature cartilage and is responsible for repairing damaged cartilage tissue [ 4 ]. Dysfunction of chondrocytes will result in degradation of the matrix, cell death and total loss of cartilage integrity [ 5 ].
WebOct 11, 2011 · Cartilage is a unique tissue characterized by an abundant extracellular matrix (ECM) 1 and a single cell type, the chondrocyte. However, the permanent hyaline cartilage, which provides the articulating surfaces of long bones and vertebrae, and the transient growth plate cartilage responsible for endochondral bone growth are uniform in neither … WebAug 16, 2024 · The chondrocyte subclusters were classified based on their potential regulatory, homeostatic, and effector functions in extracellular matrix (ECM) homeostasis. Notably, in the NP, a PROCR +... Metrics - Spatially defined single-cell transcriptional profiling characterizes ...
WebAug 16, 2024 · The chondrocyte subclusters were classified based on their potential regulatory, homeostatic, and effector functions in extracellular matrix (ECM) …
WebJun 10, 2024 · We identified six mouse chondrocyte subtypes with highly molecular fidelity to the human subtypes. This study allowed us to elucidate the full extent of … ducky youngmindtutorialsWebSome HIFs participate in the occurrence and development of OA by mediating apoptosis. Different HIFs subtypes have different effects on chondrocyte apoptosis in a hypoxic environment. For example, HIF-1α can inhibit chondrocyte apoptosis, while HIF-2α can promote chondrocyte apoptosis in the hypoxic environment. ducky yellow full keyboardWebJun 22, 2024 · Lawrence Livermore National Laboratory (LLNL) scientists have profiled articular cartilage from healthy and injured mouse knee joints at a single-cell resolution … commonwealth uk scholarshipsWebFeb 24, 2024 · Sebastian et al. 27 first reported nine chondrocyte subtypes (Ucma high, Cytl1 high, Chil1 high, Mef2c high, Krt16 high, Tnfaip6 high, S100a4 high, Neat1 high, and divC chondrocyte clusters) … commonwealth ultimate credit cardWebNational Center for Biotechnology Information common wealth uk think tankWebHypertrophic chondrocytes orchestrate endochondral ossification by regulating osteogenic-angiogenic and osteogenic-osteoclastic coupling through the production of vascular endothelial growth factor (VEGF), receptor activator of nuclear factor kappa-B ligand (RANKL) and matrix metallopeptidases-9/13 (MMP-9/13). duckz toolsWebChondrocyte trajectories analysis and IHC staining revealed that transcription factors including TCF4 were found to be highly up-regulated during the occurrence of SIFK, which might drive the reactive formation of cartilage and fibrous tissue and the activation of endochondral ossification. ... (GSE104782) data, 14 since the chondrocyte subtype ... commonwealth ultimate credit card review